Protein Phosphorylation Antibody Pairs
Cell Signaling Technology PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 50 Kit
PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 50 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 20 Kit
PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 20 Kit
Cell Signaling Technology FastScantm Phospho-Akt1 Ser473 ELISA Kit 50 Kit
FastScantm Phospho-Akt1 Ser473 ELISA Kit 50 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 5 Kit
PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 5 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 20 Kit
PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 20 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 10 Kit
PathScanR Phospho-SMAD2 Ser465467 Sandwich ELISA Kit 10 Kit
Cell Signaling Technology FastScantm Phospho-SMAD2 Ser465467 ELISA Kit 50 Kit
FastScantm Phospho-SMAD2 Ser465467 ELISA Kit 50 Kit
Cell Signaling Technology PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 50 Kit
PathScanR Phospho-SMAD2 Ser465467SMAD3 Ser423425 Sandwich ELISA Kit 50 Kit
ABclonal Technology Phospho-NFKB1-S337 Rabbit mAb
This gene encodes a 105 kD protein that undergoes cotranslational processing by the 26S proteasome to form a 50 kD DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB is a transcription regulator activated by stimuli such as cytokines UV irradiation and bacterial or viral products Upon activation NFKB translocates to the nucleus regulating genes involved in diverse biological functions Dysregulated NFKB activation is linked to inflammatory diseases while its inhibition can affect immune cell development and growth NFKB plays a key role in the immediate-early response to viral infection Alternative splicing results in multiple isoforms some of which are proteolytically processed
ABclonal Technology p-HDAC4/5/9-S246/S259/S220
Histones play a critical role in transcriptional regulation cell cycle progression and developmental events Histone acetylation deacetylation alters chromosome structure and affects transcription factor access to DNA The protein encoded by this gene belongs to class II of the histone deacetylase acuc apha family It possesses histone deacetylase activity and represses transcription when tethered to a promoter This protein does not bind DNA directly but through transcription factors MEF2C and MEF2D It seems to interact in a multiprotein complex with RbAp48 and HDAC3 [provided by RefSeq Jul 2008]
ABclonal Technology p-HDAC4/5/9-S246/S259/S220
Histones play a critical role in transcriptional regulation cell cycle progression and developmental events Histone acetylation deacetylation alters chromosome structure and affects transcription factor access to DNA The protein encoded by this gene belongs to class II of the histone deacetylase acuc apha family It possesses histone deacetylase activity and represses transcription when tethered to a promoter This protein does not bind DNA directly but through transcription factors MEF2C and MEF2D It seems to interact in a multiprotein complex with RbAp48 and HDAC3 [provided by RefSeq Jul 2008]
ABclonal Technology Phospho-Camk2-T286 Rabbit mAb
The product of this gene belongs to the serine threonine protein kinases family and to the Ca(2 ) calmodulin-dependent protein kinases subfamily Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses This calcium calmodulin-dependent protein kinase is composed of four different chains alpha beta gamma and delta The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning In addition to its calcium-calmodulin (CaM)-dependent activity this protein can undergo autophosphorylation resulting in CaM-independent activity Several transcript variants encoding distinct isoforms have been identified for this gene
ABclonal Technology Phospho-Smad2-S245/S250/S255
This gene encodes a protein from the SMAD family which functions as a signal transducer and transcriptional modulator in various signaling pathways It mediates the transforming growth factor (TGF)-beta signal regulating cell proliferation apoptosis and differentiation The protein interacts with the SMAD anchor for receptor activation (SARA) and is phosphorylated by TGF-beta receptors leading to its dissociation from SARA and association with SMAD4 This interaction is crucial for nuclear translocation where the protein binds to target promoters and forms a transcription repressor complex It can also be phosphorylated by activin receptor kinase to mediate activin signals Alternative splicing results in different transcript variants
ABclonal Technology Phospho-Smad2-S465/S467
This gene encodes a protein from the SMAD family which functions as a signal transducer and transcriptional modulator in various signaling pathways It mediates the transforming growth factor (TGF)-beta signal regulating cell proliferation apoptosis and differentiation The protein interacts with the SMAD anchor for receptor activation (SARA) and is phosphorylated by TGF-beta receptors leading to its dissociation from SARA and association with SMAD4 This interaction is crucial for nuclear translocation where the protein binds to target promoters and forms a transcription repressor complex It can also be phosphorylated by activin receptor kinase to mediate activin signals Alternative splicing results in different transcript variants