Protein Phosphorylation Antibody Pairs
ABclonal Technology Phospho-NFKB1-S337 Rabbit mAb
This gene encodes a 105 kD protein that undergoes cotranslational processing by the 26S proteasome to form a 50 kD DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB is a transcription regulator activated by stimuli such as cytokines UV irradiation and bacterial or viral products Upon activation NFKB translocates to the nucleus regulating genes involved in diverse biological functions Dysregulated NFKB activation is linked to inflammatory diseases while its inhibition can affect immune cell development and growth NFKB plays a key role in the immediate-early response to viral infection Alternative splicing results in multiple isoforms some of which are proteolytically processed
ABclonal Technology p-SMAD1/5/9-S463/S465/S467
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase and may be involved in cancer Alternative splicing results in multiple transcript variants
ABclonal Technology Phospho-Smad2-S245/S250/S255
This gene encodes a protein from the SMAD family which functions as a signal transducer and transcriptional modulator in various signaling pathways It mediates the transforming growth factor (TGF)-beta signal regulating cell proliferation apoptosis and differentiation The protein interacts with the SMAD anchor for receptor activation (SARA) and is phosphorylated by TGF-beta receptors leading to its dissociation from SARA and association with SMAD4 This interaction is crucial for nuclear translocation where the protein binds to target promoters and forms a transcription repressor complex It can also be phosphorylated by activin receptor kinase to mediate activin signals Alternative splicing results in different transcript variants
ABclonal Technology Phospho-NFKB1-S337 Rabbit mAb
This gene encodes a 105 kD protein that undergoes cotranslational processing by the 26S proteasome to form a 50 kD DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB is a transcription regulator activated by stimuli such as cytokines UV irradiation and bacterial or viral products Upon activation NFKB translocates to the nucleus regulating genes involved in diverse biological functions Dysregulated NFKB activation is linked to inflammatory diseases while its inhibition can affect immune cell development and growth NFKB plays a key role in the immediate-early response to viral infection Alternative splicing results in multiple isoforms some of which are proteolytically processed
ABclonal Technology Phospho-Smad2-S465/S467
This gene encodes a protein from the SMAD family which functions as a signal transducer and transcriptional modulator in various signaling pathways It mediates the transforming growth factor (TGF)-beta signal regulating cell proliferation apoptosis and differentiation The protein interacts with the SMAD anchor for receptor activation (SARA) and is phosphorylated by TGF-beta receptors leading to its dissociation from SARA and association with SMAD4 This interaction is crucial for nuclear translocation where the protein binds to target promoters and forms a transcription repressor complex It can also be phosphorylated by activin receptor kinase to mediate activin signals Alternative splicing results in different transcript variants
ABclonal Technology Phospho-Smad2-S245/S250/S255
This gene encodes a protein from the SMAD family which functions as a signal transducer and transcriptional modulator in various signaling pathways It mediates the transforming growth factor (TGF)-beta signal regulating cell proliferation apoptosis and differentiation The protein interacts with the SMAD anchor for receptor activation (SARA) and is phosphorylated by TGF-beta receptors leading to its dissociation from SARA and association with SMAD4 This interaction is crucial for nuclear translocation where the protein binds to target promoters and forms a transcription repressor complex It can also be phosphorylated by activin receptor kinase to mediate activin signals Alternative splicing results in different transcript variants
Cell Signaling Technology PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 5 Kit
PathScanR Phospho-Akt1 Ser473 Sandwich ELISA Kit 5 Kit
Cell Signaling Technology PathScanR Phospho-Akt1 Ser473 Chemiluminescent Sandwich ELISA Kit 20 Kit
PathScanR Phospho-Akt1 Ser473 Chemiluminescent Sandwich ELISA Kit 20 Kit
ABclonal Technology Phospho-STAT5A-Y694 Rabbit pAb
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Cell Signaling Technology PathScanR Phospho-Akt1 Ser473 Chemiluminescent Sandwich ELISA Kit 50 Kit
PathScanR Phospho-Akt1 Ser473 Chemiluminescent Sandwich ELISA Kit 50 Kit
ABclonal Technology Phospho-Smad2-S467 Rabbit pAb
This gene encodes a SMAD protein, which mediates signaling in the TGF-beta pathway and regulates processes like cell proliferation, apoptosis, and differentiation. It interacts with the SMAD anchor for receptor activation (SARA) protein and is phosphorylated by TGF-beta receptors. Phosphorylation leads to dissociation from SARA and association with SMAD4, facilitating its nuclear translocation. In the nucleus, it forms a repressor complex with cofactors to regulate gene expression. This protein can also be phosphorylated by the activin type 1 receptor kinase to mediate activin signaling. Alternative splicing produces multiple transcript variants.
ABclonal Technology Phospho-Smad5-S463/S465 Rabbit pAb
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants.
ABclonal Technology Phospho-AKT1-T450 Rabbit pAb
This gene encodes a member of the AKT serine-threonine kinase family (protein kinase B alpha, beta, and gamma). These proteins, which share a pleckstrin homology domain, a kinase domain, and a regulatory domain, are phosphorylated by phosphoinositide 3-kinase (PI3K). AKT/PI3K plays a key role in signaling pathways involving receptor tyrosine kinases, G-protein coupled receptors, and integrin-linked kinase, regulating functions like cell proliferation, survival, metabolism, and angiogenesis. Full activation of AKT1 requires phosphorylation at threonine 308 and serine 473. AKT1 is involved in apoptosis suppression, tumor cell survival, and the mTOR pathway, which regulates protein synthesis. Mutations in this gene are linked to various cancers and conditions like Proteus syndrome and Cowden syndrome. Multiple alternatively spliced transcript variants exist.